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A-Z of some sexist issues men face
This is NOT to play opression olympics. This is just to show there are some issues, that usually are not discussed, highlighted or mocked. Yes some of these are kind of funny examples, but hey we have seen don't manspread while running, air conditioning is sexist against women and icebergs are sexist so here goes:Academia - typically conforms to patriarchy-adherent male-blaming dogma
Addiction – men suffer more than women, partly due to extra stresses faced
Aeroplanes – only men are not permitted to sit next to unaccompanied minors
Alcohol – a man can be prosecuted if a woman gets drunk then cries rape
Alimony - disproportionately targets men, even when women main earners
Anonymity - after rape/DV claims, men publicly named without evidence
Anorexia - blamed on male gaze. Death-rate inflated 3000 fold by victim-fems
Anti-male shaming tactics – typical ways men demanding equality get attacked
BBC bias –world's largest broadcaster uses male-blaming victim-femalism
Birth certificates – father's name not legally required to be listed[9.5]
Boxing – men must fight 12x3 minute rounds, women, only 10x2
Campus rape hysteria – yet funded 'hotlines' receiving virtually no calls
Cancer – men with cancer treated less effectively than women
Charities – often exaggerating female victim statistics for financial gain
Child abuse- men typically shown as perpetrators - women kill & abuse more
Childbirth – its risks exaggerated (as excuse to block men's equality debates)
Child custody cases – 7% of UK fathers allowed to live with their children
Chivalry – men placating women and dismissing men's equality issues
Circumcision – only legal when males are being mutilated
Civilization – 90% of patents awarded to men, yet men portrayed negatively,
Clip joints – women lure men into clubs to be extorted by threats of violence
Combat deaths – usually male. Female soldiers paid same, but kept safer
Conscription – men enslaved for longer, & only men forced onto front line
Contraception – women have several effective options, men barely one
Commuting – men travel further than women to get to work
Dating protocols – most women still expect money and gifts from men
'Deadbeat Dads' criticized, though non-custodial moms even worst payers
Death jobs – 95% of workplace fatalities are of men
Discrimination laws written with female focus, so sex-discriminatory their self
Disease – men get more of most, but less funding, and less treatment
Doctor's surgery hours – less opportunity for working men to visit GP
Domestic violence arrest policies remove man only
Domestic violence shelters for women and their children, but not men
Domestically violent women use more arms, poison, surprise & premeditation
Dominance – men portrayed as controlling, but research find women boss men
Double standards of female-only equality advocacy across issues
Dress codes - Neck-ties typically compulsory for male employees only
Drinks spiking myth – media creating more rape hysteria– yet no evidence
Driving – men are more often the family chauffeur than women
Driving Skills – men denigrated, but per mile, safer drivers than women
Earnings – women earn more per hour of work-related activity than men(go to Neil Cuvuto show link at hyperlinked page)
Equality agencies - actively exclude reference to men and men's equality issues
Engagement gifts – men only still expected to purchase diamonds etc
Environment – men typically blamed for causing pollution[44.5]
European Union – complies with victim-female strategic frames and focus[pending]
Executions – men disproportionately targeted by governments for death
False allegations epidemic, covered up by mainstream media and v-feminists
False allegations against men rarely prosecuted, but instead 'no crimed'
Fatherlessness – bad on every measure, yet encouraged by some feminists
Fathers - disproportionately denied access to children
Fees – UK parents pay for daughters' further education more than for sons'[pending]
Female revenge rhetoric seen as justifiable by media narratives
Female supremacism rhetoric seen as 'empowering' by establishment
Feminism - presumed perfect by elite, so abuses of men get overlooked
Forced labour – men the majority of those genuinely trafficked into slavery
Funding – for women's initiatives in universities, but not for men's
Gender studies - hyper-focusses on women and ignores men's issues
Gender-developmental progress – men typically presented as hostile to it
Genital injuries to men - seen as joke by mainstream media regulators
Glass ceiling myth – elite pretend women being held back in employment[60
Governmental agencies - for women's issues but not men's
Health spending – women's disease research gets more funding than men's
Higher education – 59% of degrees go to women, 41% men, the gap widening
Historiography – women presented as historically oppressed, and by men
Homelessness – 80% to 90% of street homeless are men
Homophobic violence – gay men overwhelming victims from people, and states
Housework – Muslim husbands obliged to provide wife with a housekeeper
Hypergamy - (gold-digging) - prevalent amongst majority of world's women
Ideology – Marxist left wing claim only women face discrimination
India – 98% of domestic violence allegations believed false
Infrastructure – in US from 1890 to 1917, 230,000 men killed on rail roads
Inheritance – Muslim women not obliged to share property but men must
Innocence Project – 99.5% of all found to be wrongly convicted, are men
International Women's Day celebrated, but Men's Day ignored or disparaged
Judiciary - recommend discriminating against men when setting sentencing
Koran – decrees that women are weak so should be provided for by men
Lace Curtain – excludes men's issues debates from mainstream media
Ladies Nights – men still financially discriminated against for being men
Language – negative terms associated with maleness i.e. 'slugs and snails... '
Life expectancy - shorter for men around the world
Male-bashing – Newspaper marketing Association recommends misandry
Male idiot stereotype - omnipresent in sitcoms and adverts
Male Studies – falsely framed by mainstream media as anti-women or anti-equality[82.5] [82.6]
Man flu - scoffed at, despite science showing men more susceptible to flu
Marriage gifts – cultures and religions insist men must pay women to marry
Media bias – factual content portrays men negatively 69% of time
Men's rights movement, issues & activists presented as anti-women & equality
Millionaires – 25% more young female millionaires than male in the UK
Ministers for Women but none for men
Misandry - common but seldom mentioned, or recognized in dictionaries
Misogyny - claims of it used to silence any male dissent
Mitigation – 12 female-only legal defences for pre-meditated murder
Murders - of men, much more frequent than of women
NGOs – use victim-female strategies and focus in their advocacy and research
News reporting – avoids reference to gender when the victims are male
Nursery education – boys treated worst than girls, and male teachers excluded
Objectification - typically presented as something only women suffer from
Overtime – 60% of men in UK work over 60 hours per week
Parental alienation – men disproportionately targeted by women
Parental leave & pay – UK Fathers get 26 times less than UK mothers
Parental leave & pay – mothers can withhold parental leave & pay from men
Part-time work – UK men earn 4% less than part-time women
Paternity fraud – 30% non-custodial fathers paying for children not theirs
Paternity testing for every newborn - not yet compulsory anywhere in world
Patriarchy theory - omnipresent throughout academy, media and polity[103.5]
Paedophilia hysteria - typically presents men only as the threat
Policing – men arrested more often than women for similar crimes
Porn – male porn stars get paid nine times less than female porn stars
Porn – female porn stars can choose male co-stars, but males get no choice
Porn – male porn stars body-build to get screen-ready. Females just show up
Primary education – anti-male propaganda introduced, & few male teachers
Primary care giver payouts – women rewarded in divorces for not earning
Princess culture – girls being indoctrinated to expect special treatment
Prison conditions – much worst for men than for women
Prostitution – male customers criminalized, female sellers treated as victims
Pussy pass – women held to lesser standards than men due to genitalia
Quotas - usually only enforced to correct inequalities faced by women
Rape of men - often treated as a media joke
Rape (of women) statistics inflated by educators, governments & media
Relational aggression – females of all ages slightly more manipulative than males[115.5]
Religions - insisting on and enforcing male wage-slavery to wives and sisters
Reproductive rights & choices – men, no choice with unwanted pregnancies
Retirement age – 5 years later for men, despite shorter life expectancies
Sabotage – men's rights movement aims attacked and obscured in wikipedia and beyond[118.5] [118.6]
Seating – In Saudi Arabia, two men must vacate bus seat for one woman
Secondary education – Male-blaming victim-femalism taught across curricula
Second shift myth – claims 'women's work never done' - yet men do more
Sentencing bias – being male is number one predictor of a heavier sentence
Sex – women less likely to initiate or reciprocate sexual acts than men[pending]
Sexism – women 4 times more sexist, but some fems pretend only men sexist
Sex segregation – cultures & feminisms say men too predatory to integrate
Spending decisions – wives decide on 90% of purchase decisions in marriages
Statutory rape – boys portrayed as lucky when teachers sexually abuse them
Student Unions - ignore men's issues, and object to men's equality groups
Suicide – in part due to inequalities, a higher risk for men at every age group
Suicide bombers - disproportionately male. Family of man receive a pay-off
Taxes - men pay more than women, but receive less back in state benefits
Tennis – men forced to play best of 5 sets where as women play best of 3
Tips – waitresses earn $2000 more gratuities than waiters per year
Trafficking lies – women choosing prostitution presented as if victims of men
Victim-female statistics abuse - at every level of the establishment
Violence – most of women's violence is against men (as is men's violence)
Wage gap lies – victim-femalists falsely claims women unfairly paid less
Wage slavery – religious & cultural laws decree men must pay for women
War – historically, 99.999% of combat fatalities have been men
Wealth – women control 60% of all money in the USA
Wigs – men publicly scorned for wearing wigs, whilst women given a pass [141.5]
Women & children first policies in advocacy, emergency aid, & evacuations)
Woman's Hour six times a week on the BBC, but no Men's Hour or the like
Women's academic forums but no men's, so widespread ignorance on men
Women's groups & governments oppose joint custody [145.5]
Women's groups exaggerate prevalence of rape and domestic violence
Women's issues TV shows, but no men's issues shows
Women-only political advocacy rhetoric, from far left to far right wings 
Women-only public spaces, like gyms, swimming baths, parks and islands[15o] 
Women-only train carriages [152.5]
Women's-only issues representation by student unions
Women-only research in academia
Women's studies departments – 900 or more women's & gender studies depos ignoring men
United Nations – promotes women's inequality stories
Universities' curricula and culture, across fields, uniformly critical on men
Unpaid security guard role expected of men by many women
XY 'inferiority' rhetoric common, although science does not support the claim
Zero – the number of men's rights movement books most people have read
DD: Zafgen (ZFGN)
Zafgen was founded in 2005. Its main objective is to treat severe obesity. Zafgen's main drug is called beloranib, an injectable weight loss drug. Zafgen licensed beloranib for worldwide use (except South Korea) from CKD Pharma, which originally discovered the drug, and its use, after several years of research into it.
Beloranib, an analog of the natural chemical compound fumagillin, is a METAP2 inhibitor. METAP2, among other things, is an enzyme that helps create new blood vessels. The theory goes that if you inhibit METAP2, you inhibit fat growth, and this is indeed what has happened in Phase 2 trials, the first of which ended in 2013.
Zafgen has been conducting multiple beloranib trials, including, prominently, for PWS -- short for Prader–Willi syndrome, a rare genetic disorder that causes, among other things, obesity and hyperphagia, or uncontrolled eating/hunger. This trial is called ZAF-311. There is also a planned (mostly) European trial, for European approval, called ZAF-312. Beloranib has an orphan drug designation in Europe.
Then, Columbus Day rolls along. Stock market open but many businesses closed -- including Zafgen. Zafgen cancels investor conferences. No one knows why. Lots of speculation. People think maybe a patient in a trial died? Adam Fuerstein bashes it for saying nothing as the stock crashes, and the stock plunges further.
By then I'm already looking into it.
Stock is at $14 on Thursday, October 14. ~55% haircut on no news. I consider buying it. Chicken out. Then there's a trading halt. Patient death announced. Stock crashes 10% after the halt. Restarts again. I still don't buy. Stock crashes AGAIN to high 10s. I still don't buy.
Meanwhile I am posting on Yahoo Messageboards that death might be good news for stock -- why? because patient death rate for those who aren't even on the trial (prader-willi syndrome PWS) is a historical 3% already, and, importantly, the FDA isn't halting the trial. I'm a stock whisperer. Stock doubles up in the next few hours as shorts get absolutely ripped apart.
Right at this moment, no one knows (including Zafgen) if death is patient on placebo or beloranib. 33% chance it was on placebo. Friday, Zafgen is informed by those running the trial that death was on beloranib, and informs investors that 6 thrombotic events happened in 450 patients on beloranib in all its trials, versus 0 in placebo. FDA sets a partial clinical hold on all current trials (ZAF-311 and ZAF-203) -- which requires Zafgen to run a thorough thrombotic disease risk assessment for current patients, and requires Zafgen to run ZAF-312 (mostly Europe but some US patients) after a risk and efficacy assessment and discussion with the FDA.
Insane bloodbath ensues that Friday. Stock runs down all day to low $10s. I buy in half my position, then the other half next week.
Zafgen decides to end the randomized portion of both current trials early (ZAF-311 being about 90% complete) a few days later. Since ZAF-311 has a non-randomized open label portion, they can still stay on the drug after trial completion for a few months. All but 2 patients, as evidenced by the ER yesterday (November 10) elect to stay on to receive the drug in ZAF-311. (even those on placebo)
No one even knows whether beloranib actually caused the thrombotic events, but the stock price is what it is.
Beloranib has had good success in all Phase 2 trials so far in reducing weight. You can find some posters on Zafgen's site here: http://www.zafgen.com/zafgen/newsroom/media-library (click the SCIENCE tab) The Phase 2 trial showed a 60% hyperphagia (uncontrolled hunger as mentioned earlier) and rapid weight loss. (about 11% in 12 few weeks in the Phase 2 PWS patients)
There's also a decent amount of Seeking Alpha articles.
In the CC yesterday, (November 10), 5 of the now 7 events (the death was preliminarily caused by a thrombotic event) are dismissed as entirely unrelated to beloranib. That, coupled with hyperphagia reduction and weight loss benefits (optimistically, 20-30%), means in my opinion that this drug will likely be approved by the FDA and its European counterpart, and become part of the standard of care for PWS patients as, at the very least, an orphan drug. I estimate conservatively about $480-$720 million in yearly revenue just from PWS and severe obesity in Europe and the US.
Here is the CC Seeking Alpha transcript and earnings presentation slides.
The CC also showed how important PWS treatment is, and potentially provided a signal of safety and efficacy, with only 2 patients out of 101 deciding to opt out of the open-label extension. The data for the ZAF-311 trial will be released in Q1 of 2016.
I see this climbing back up to high 20s or even high 30s within a month.
Importantly, hedge funds have not sold off their positions and one new hedge fund has a large position in it (Foresite Capital)... I think 5.5%, although I am not 100% sure.
There's probably tons of stuff that I missed here but that's the gist of it.